Ketones: What They Are and How to Leverage Them For Greater Health and Longevity

Ketones have gained significant attention in recent years, particularly in relation to the ketogenic diet. But what exactly are ketones? Recently Dr. Latt Mansor, pioneer in performance nutrition and metabolic health and Research Lead at H.V.M.N, joined us to discuss how to leverage keytones for greater health and longevity. What follows is a summary of the podcast discussion.

How the Body Generates Ketones and Induces Ketosis

While ketones have been known for their role in providing an alternative fuel source for the brain during periods of fasting or low carbohydrate intake, recent research has uncovered additional benefits. Dr. Mansor highlights that BHB has been shown to increase brain activity and has signaling effects on the DNA level, potentially influencing metabolic health.

Traditionally, ketosis was achieved through the ketogenic diet or fasting. However, with the emergence of exogenous ketones, individuals can now increase their blood ketone levels without the need for strict dietary restrictions. Latt explained that exogenous ketones come in various forms, including ketone salts, MCT oil, and ketone esters.

Ketone salts, which are BHB molecules bound to a salt molecule, have limitations in terms of raising blood BHB levels and can cause gastrointestinal issues at high doses. MCT oil, while not a ketone itself, can be converted into ketones by the liver but does not raise blood BHB levels significantly. Ketone esters, on the other hand, are BHB molecules bound to another molecule in an ester bond. When ingested, the ester bond is cleaved in the gut, allowing BHB to enter the bloodstream and provide a slow release of ketones.

Using Ketones for Improved Workouts and Endurance

One of the primary applications of exogenous ketones is in performance optimization for athletes. Dr. Mansor explains that ketones have been shown to have a glycogen-sparing effect, improve recovery, and provide cognitive benefits. Athletes have reported improved performance and endurance when using exogenous ketones, even at lower doses. The optimal blood BHB level for performance is between one and two millimolar.

In addition to performance enhancement, ketones have shown promise in the field of cognitive function. Users have reported increased clarity and focus for several hours after consuming exogenous ketones. Studies have demonstrated that ketones can improve brain network stability and may have anti-inflammatory properties, making them a potential therapeutic option for traumatic brain injury and neurodegenerative diseases such as Alzheimer's.

Latt mentions ongoing research on the effects of exogenous ketones on heart health. Animal studies have shown that ketones can mitigate cardiomyopathy and improve cardiac function. Preliminary studies in humans have also indicated potential benefits for heart failure patients.

Ketones and Metabolic Health: Unlocking the Potential

In conclusion, the world of ketones and metabolic health is a rapidly evolving field with exciting potential. Exogenous ketones, such as Ketone IQ, offer a tool for optimizing performance, cognitive function, and potentially addressing various health conditions. Ongoing research is shedding light on the mechanisms of action and expanding the applications of ketones in areas such as traumatic brain injury, cardiovascular health, and neurodegenerative diseases. As we continue to unlock the potential of ketones, it is crucial to approach their use as part of a comprehensive approach to health optimization, including proper nutrition, exercise, sleep, and stress management. 

The future of ketones and metabolic health holds great promise, and HVMN is at the forefront of this exciting field. With ongoing research and development, we can expect further advancements in taste, formulation, and understanding of the potential benefits of ketones. As we continue to explore the possibilities, it is essential to approach this field with curiosity, open-mindedness, and a commitment to evidence-based practice. Together, we can unlock the full potential of ketones and metabolic health for a healthier and more optimized future.

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