The Bestseller Bundle

Trans-Resveratrol (trans-3, 5, 4'-trihydroxystilbene) in Qualia NAD+ is usually just called resveratrol. It is a stilbenoid, a type of natural polyphenol found in plants. Resveratrol has been the subject of thousands of pre-clinical and clinical research studies. It is best known for supporting healthy aging functions, and for supporting metabolism, heart health, immune health, and cognition.* Resveratrol is a defense compound that plants make more of when exposed to environmental stressors. It toughens them up, making them more resistant to stress.

Magnesium (from Aquamin® MG)in Qualia NAD+ Magnesium is one of the most abundant minerals in the body and plays a vital role in supporting the function of all living cells. It’s used in more than 300 enzymes. ATP (i.e., cellular energy) occurs complexed with magnesium, so all enzymes utilizing ATP require magnesium to support their activity. ATP production, particularly through mitochondrial processes, promotes greater NAD+ turnover (the continuous use and recycling of NAD+).

Coffeeberry® in Qualia NAD+ is made from organic coffee fruits, which are often called coffee cherries. Like cherries, coffee plants produce soft red fruits surrounding a pit or hard seed. The seed (or coffee “bean”) is roasted to make coffee. But it’s the fruit that is being used to make Coffeeberry®. Similar to many fruits, coffee cherries are high in polyphenols. And like coffee beans, they also contain caffeine. Caffeine has been found to activate AMPK, a key energy-sensing enzyme that plays a significant role in promoting NAD+ biosynthesis.*

B-Complex Vitamins (from Saccharomyces cerevisiae culture) in Qualia NAD+ is an inactivated yeast that provides all eight B vitamins (and thus 8 ingredients within the Qualia NAD+ formula): thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). B vitamins have essential roles in cellular metabolism and energy production. Every B vitamin is either a cofactor or a precursor of a cofactor for a key metabolic process. B vitamins are essential for the generation of cell energy as ATP in mitochondria.

Sabroxy® (Oroxylum indicum bark extract) is made from the dried bark of the Indian trumpet tree/ (Oroxylum indicum). It supports healthy brain-derived neurotrophic factor (BDNF) function, helping to maintain neurological health and nerve functions. Sabroxy contains a flavonoid called oroxylin-A that supports healthy dopamine signaling which supports motivation and focus.*

Coffeeberry® Whole Coffee Fruit Extract is made from organic coffee fruits; it contains naturally occurring caffeine and polyphenols found in the fruit which promote healthy activity and energy metabolism in the brain. It also indirectly supports the healthy release of neurotransmitters like dopamine and serotonin.*

Cognizin® A clinically studied source of choline (found in various animal products and vegan foods such as nuts and cruciferous vegetables) and cytidine. It supports healthy acetylcholine production, an important neurotransmitter involved in attention, concentration, learning, memory, and neuroplasticity.*

Phosphatidylserine (from sunflower lecithin) is a phospholipid from sunflower lecithin, and brain-essential nutrient. It is a major phospholipid in the brain, supporting healthy membrane and neurotransmitter signaling, especially in parts of the brain related to memory functions.*

Acetyl-L-Carnitine HCl: an acetylated form of L-carnitine. This form of carnitine crosses the blood-brain barrier and is the preferred form for use in brain and nervous system support. It supplies carnitine and acetyl groups that collectively support the healthy production of acetylcholine neurotransmitter molecules, brain energy production, and neuroprotective functions.*

N-Acetyl-L-Tyrosine: N-acetyl-L-tyrosine (NALT) supplies the amino acid L-tyrosine, which is a building block for dopamine and catecholamine neurotransmitter molecules involved in supporting motivation, focus, and executive functions.*

Taurine: one of the most abundant amino acids in the brain and eyes, where it supports brain health, hearing, and vision. It’s involved in promoting long-term potentiation, healthy GABA and glycine neurotransmission, optimal function fo brain-derived neurotrophic factor (BDNF), neuronal mitochondrial function, neuroprotection, and photoreceptor cell visual function.*

L-Theanine: an amino acid found in the leaves used to make green and black teas. It promotes activity in the alpha frequency band; this frequency of brain waves is characteristic of attention and relaxation of the mind without drowsiness. L-theanine promotes focused attention, mental alertness, and calm, relaxed energy.*

L-alpha-Glycerylphosphorylcholine (alpha GPC): a choline form found in the brain. It supports healthy acetylcholine production, an important neurotransmitter involved in attention, concentration, learning, memory, and neuroplasticity. Alpha GPC also supports phospholipid metabolism in the brain, which is important for keeping brain cells healthy.*

Guarana Seed Extract: a caffeine-containing plant native to the Amazon, where it was used to stay awake longer and support brain performance. Similar to other caffeine-containing plants, it promotes optimal activity and energy metabolism in the brain. It also indirectly supports the healthy release of neurotransmitters like dopamine, and serotonin, which are involved in alertness, feelings of energy, mood, and motivation.*

Caffeine (anhydrous): Caffeine is the most widely used nootropic substance in the world. It promotes healthy activity and energy metabolism in the brain and nervous system. It also indirectly supports the healthy release of neurotransmitters like dopamine and serotonin, which are involved in alertness, feelings of energy, mood, and motivation.*

Pyrroloquinoline Quinone disodium: also known as (PQQ) is a vitamin-like antioxidant compound. It supports optimal activity, blood flow, and oxygen metabolism in areas of the prefrontal cortex involved in thinking, attention, and memory. PQQ also supports healthy energy production, mitochondrial health, and cellular protection and repair functions.*

Boron (as boron glycinate): Boron is a trace mineral. It is best known for supporting bone health and optimal sex hormone levels. Studies suggest it may also be a brain-essential nutrient. Adequate dietary intake of boron is needed to support healthy brain electrical activity and cognitive performance, especially in areas related to attention and memory.*

Vitamin C (as ascorbic acid): Vitamin C is a brain-essential nutrient. It’s best known for its neuroprotective support as an antioxidant. Vitamin C is involved in the conversion of dopamine to noradrenaline and helps dampen neuronal over-stimulation by glutamate. It also promotes the regulation of catecholamines and acetylcholine from synaptic vesicles and the formation of myelin.*

Vitamin D3 (as cholecalciferol from VegD3®): VegD3® is Vitamin D3 (cholecalciferol) produced from a non-GMO algal source. Vitamin D3 is a fat-soluble vitamin and a brain essential nutrient involved in the healthy growth and function of neurons by supporting brain‐derived neurotrophic factor (BDNF), glial‐derived neurotrophic factor (GDNF), nerve growth factor (NGF) and other neurotrophic factors. Adequate vitamin D3 is needed for healthy dopamine signaling, neuroprotective functions, and neuroplasticity.*

Thiamine (as thiamine HCl): Thiamine (B1) is a member of the B-complex vitamin family and a brain essential nutrient. It supports healthy brain energy metabolism, neuron health, neurotransmission, and adrenal gland function. Thiamin helps synthesize several neurotransmitters involved in focus, memory, motivation, and mood, including acetylcholine, dopamine, and GABA.*

Riboflavin: Riboflavin (B2) is a member of the B-complex vitamin family and a brain essential nutrient. It supports optimal brain energy production, the production of glutathione (a cellular antioxidant), and healthy adrenal function. Riboflavin is needed for myelin and is used in the metabolism of fats, which is critical in the brain since it is mostly made of fats.*

Niacin (as Niacinamide): Niacinamide (B3) is a member of the B-complex vitamin family and a brain essential nutrient. It supports healthy NAD+ levels, energy production, antioxidant defenses, and cellular repair and stress response functions. Vitamin B3 is critical for maintaining the health of the central nervous system (i.e., it’s neuroprotective).*

Vitamin B6 (as pyridoxal 5'-phosphate): Vitamin B6 is a member of the B-complex vitamin family and a brain essential nutrient. Pyridoxal 5'-phosphate is a coenzyme (i.e., active) form of vitamin B6. It supports the healthy production of brain glucose and energy metabolism. Vitamin B6 is directly or indirectly needed for supporting the production of neurotransmitters related to motivation, focus, and mood, including acetylcholine, dopamine, GABA, and serotonin.*

Folate (as L-5'-methyltetrahydrofolate calcium): Folate (B9) is a member of the B-complex vitamin family and a brain essential nutrient. L-5'-methyltetrahydrofolate calcium is a coenzyme (i.e., active) form of folate. It supports the healthy function of brain and nerve cells, and is needed for the production of myelin. Folate is involved in promoting healthy dopamine, melatonin, noradrenaline, and serotonin, and supports healthy hearing, mood, and vision.*

Vitamin B12 (as methylcobalamin): Vitamin B12 is a B-complex vitamin and a brain essential nutrient. Methylcobalamin is the coenzyme (i.e., active) form of vitamin B12, and the preferred nootropic form. It supports the healthy function of brain and nerve cells, and is needed for the production of myelin. Methylcobalamin is involved in promoting healthyg dopamine, melatonin, noradrenaline, and serotonin, and supports healthy hearing and vision.

Biotin: Biotin (B7) is a B-complex vitamin and a brain essential nutrient. It supports healthy glucose metabolism, which is important because the brain is particularly sensitive to the delivery and metabolism of glucose. Adequate dietary biotin is also important for healthy dopamine neurotransmission.*

Pantothenic Acid (as calcium pantothenate): Pantothenic acid (B5) is a B-complex vitamin and a brain essential nutrient. It supports healthy brain energy production, the synthesis of neurotransmitters (most notably acetylcholine), the production of the myelin required for healthy nerve function, and adrenal function (it’s often referred to as the “anti-stress” vitamin).*

Magnesium (as magnesium aspartate): Magnesium (Mg) is a brain essential mineral. It is needed for the optimal production of dopamine and serotonin, and plays a role in supporting other neurotransmitters, including GABA and glutamate. Mg is also an essential factor in making and activating ATP (brain energy), nerve transmission, blood-brain barrier integrity, a healthy stress response, and hearing and vision.*

LUTEOLINis a yellow plant pigment used for centuries as a yellow dye. In fact, the latin name for yellow is luteus. Luteolin has a very similar molecular structure to quercetin, and much like fisetin, luteolin has also shown evidence of senolytic properties by helping to manage senescent cell elimination.

LONGVIDA OPTIMIZED CURCUMIN® EXTRACTCurcumin is the pigment in turmeric that results in its yellow-orange coloring. Curcumin appears to have senolytic potential in intervertebral disc cells, but much like quercetin, it has poor bioavailability. LONGVIDA OPTIMIZED CURCUMIN® EXTRACT was developed to overcome this bioavailability hurdle and has been researched in human studies in areas including cognitive function, mood, exercise recovery, and joint health.

PIPERLONGUMINE (FROM PIPER LONGUM ROOT EXTRACT) is an alkaloid found in many species of pepper plant, and found in abundance in the Asian long pepper plant (Piper longum), particularly in its root structure from which we source our piperlongumine. It is the only natural compound known to support a novel mechanism that helps manage senescent cells called oxidation resistance 1 or OXR1.

OLIVE LEAF EXTRACT Oleuropein (a secoiridoid polyphenol) is found in high amounts within olive leaves. Our particular olive leaf extract is standardized for 40% oleuropein. A 2020 study showed that oleuropein supports the management of senescent chondrocytes—chondrocytes are the cells that create cartilage and support healthy joints (an area of our bodies which commonly experience noticeable negative aging symptoms).

MILK THISTLE FRUIT EXTRACT The seed-like fruits from milk thistle (Silybum marianum) have been in Mediterranean diets for over 2,000 years. The main active substance in milk thistle is silymarin. Our extract is standardized to 80% silymarin by spectrophotometry, and has potential in playing a complementary role to other ingredients in Qualia Senolytic, particularly the stressed cell support of curcumin.

SOYBEAN SEED EXTRACT Soybean seeds, like most legumes, contain a type of bioflavonoid called isoflavonoids. Our soybean seed extract is standardized at 40% isoflavones which shows promise as a having a complementary role in our overall formulation. Daidzein, for example (an isoflavonoid in our extract) is one of the top four compounds identified as a possible candidate for helping manage some types of senescent cells.