We recommend taking all 6 capsules of Qualia Senolytic one day, and the following day, take the other 6 capsules. It doesn't matter if you take them all at once or spread throughout the day. While there are no special instructions for getting started, a good way to introduce anything new is to start small and increase over time. Rather than taking the full recommended dose of 6 capsules a day on 2 back-to-back days during the first month, it’s fine to start by taking a lower dose and spreading it out over a few more days, or to start at a lower dose and eventually build up to the recommended dose.  Our general recommendation is to take Qualia Senolytic with food. The reason for this recommendation is because (1) with food is the most common way senolytics have been used in studies, and (2) Qualia Senolytic contains concentrated food extracts, some of which may be more bioavailable if taken with food.  When we tested Qualia Senolytic prior to launch, some participants chose to take it with food and others took it without food. So, if taking supplements on an empty stomach is something that you tolerate well and find more convenient, feel free to take it without food. We would also recommend drinking some extra water during the two day treatment. I hope that helps! Please let us know if you have any further questions.