Huperzia serrata Leaf extract (1% Huperzine A)

Huperzia serrata (synonym Lycopodium serratum) is a species of fir clubmoss that has been used in Traditional Chinese Medicine (as Qian Ceng Ta). Huperzia serrata has several bioactive compounds, including lycopodium alkaloids, triterpenes, flavones and phenolic acids. The most important and widely studied of these is the alkaloid huperzine A, which indirectly supports healthy acetylcholine levels in the brain. Acetylcholine is a neurotransmitter and neuromodulator that plays important roles in cognitive function, most notably, in the neural mechanisms of memory [1], but also in executive function, alertness, attention, and learning. Acetylcholine supports different types of memory, from working memory to long-term memory, and different phases of memory, from memory formation to consolidation and retrieval. By supporting acetylcholine signaling, huperzine A supports cognitive function. Huperzine A has also been shown to support brain antioxidant defenses and neuroprotective functions [2,3].*


TOP BENEFITS OF HUPERZINE A

Supports cholinergic neurotransmission *

Supports brain function and cognition *

Supports neuroprotective functions*


NEUROHACKER’S HUPERZINE A SOURCING

Huperzia serrata leaf extract is made from the aerial parts of the plant. It is standardized for 1% Huperzine A.

Huperzia serrata leaf extract is non-GMO, gluten-free and vegan.


HUPERZINE A FORMULATING PRINCIPLES AND RATIONALE

Persons using huperzine A as a nootropic typically take a serving ranging from 50 to 200 μg. Qualia uses an amount consistent with the lowest end of this range (50 μg). On Qualia products, the labeled amount (e.g., Huperzia serrata Leaf Extract (1% Huperzine A) is 5 mg ) refers to the amount of the Huperzia serrata Leaf extract not to the amount of huperzine A. Because the extract is standardized for 1% huperzine A, and each milligram of H. serrata leaf extract provides 10 μg of huperzine A, a 5 mg serving of the extract supplies 50 μg of huperzine A. We opted for a serving at the low end of the range because we believe huperzine A is additive with other ingredients used in our formulation for supporting brain health.*

 

HUPERZINE A KEY MECHANISMS

Supports brain function and cognition*

Supports memory and learning* [4–9]

Supports cognitive health* [4–6,8–16]

Supports task switching* [15]

Supports long-term potentiation (LTP)* [17]

Supports acetylcholine signaling* [2,4,5,10,18–22]

Supports dopamine signaling* [4,19,20,22]

Supports noradrenaline signaling* [4,20,22]

Influences NMDA glutamate receptor activity* [4,23–26]

Supports the levels of neurotrophic factors (BDNF, NGF)* [27]

Supports hippocampal neurogenesis (in animals)* [28]

Supports neuroprotective functions* [3,4,11–13,17,20,21,27,29–35] 

Supports brain antioxidant defenses* [3,12,30–34,36]

Supports neurovascular health* [37]

Supports blood-brain barrier function* [37]

Influences neural cytokine signaling* [10,37–39]


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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