NooGandha® Liposomal Ashwagandha (Withania somnifera) Root and Leaf Extract

Noogandha^® is a clinically studied liposomal ashwagandha extract. The "Noo" (for nootropic) gives away the reason it was developed and its emphasis—cognitive performance. Ashwagandha (i.e., Indian ginseng) is a Rasayana—the category of elixirs and tonic herbs prized by the branch of Ayurvedic medicine concerned with rejuvenation, and focused on promoting a youthful state of physical and mental health. Ashwagandha holds a prominent place among the Rasayana herbs, where it was used for many reasons including as general tonic and to infuse energy and vigor in circumstances characterized by exhaustion or a lack of physical energy. A key attribute is that ashwagandha promotes balance. As the English name Indian ginseng implies, ashwagandha was believed to share some of the attributes of ginseng, in essence supporting multiple areas of health and well-being, especially under conditions characterized by increased stress. Herbs that promote these types of nonspecific resistance to and recovery from stress—and which typically also support general well-being, healthy energy, and homeostasis—are called adaptogens.  In two randomized, double-blind, placebo-controlled human trials, NooGandha^® supported cognitive function and a healthy stress response.* 

Top Benefits of NooGandha^® Liposomal Ashwagandha

Supports healthy stress resistance*

Supports cognitive performance*

Qualia’s NooGandha^® Liposomal Ashwagandha Sourcing

NooGandha^® is an ashwagandha root and leaf extract whose composition and research demonstrate support for cognitive function. NooGandha^®’s extraction process focuses on specific compounds with nootropic bioactivity, with less of the compounds that show a calming effect while still retaining the stress support benefits of ashwagandha.* 

NooGandha^® is made from ashwagandha grown in India and standardized to contain not less than 4% withanolides. 

NooGandha^® is a registered trademark of Specnova LLC, USA.

NooGandha^® is a non-GMO, gluten-free, and vegan ingredient.

NooGandha^® Liposomal Ashwagandha Dosing Principles and Rationale

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Qualia Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. The studied dose range for NooGandha^® is 225-400 mg [1,2]. In a 30-day study that compared 225 mg and 400 mg doses, the better overall combination of cognitive and stress support occurred with the lower dose [1]. We opted to recommend a  225 mg dose to be consistent with the results of this study, as well as with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.*

Withania somnifera Key Mechanisms

Supports brain function*

Supports cognitive performance* [1,3–5]

Supports GABA signaling* [6–10]

Supports dopamine signaling* [11]

Influences acetylcholinesterase activity* [11]

Supports neuroprotective functions* [11–14]

Influences neural immune signaling* [14,15]

Supports healthy mood and stress response*

Supports a calm mood* [1,15,16]

Supports healthy stress responses* [17–19]

Supports healthy stress hormone levels* [1,17–19]

Promotes healthy sleep*

Supports sleep onset and total sleep time* [9,16]

Supports sleep efficiency* [16]

Supports quality of sleep* [16,20]

Supports slow wave sleep* [9]

Supports mitochondrial structure and function*

Supports mitochondrial function and structure* [13,21]

Supports electron transport chain activity* [11–13,22]

Supports citric acid cycle enzymes* [22]

Promotes exercise performance*

Supports endurance performance* [23,24]

Supports muscle strength* [20,25]

Supports post-exercise recovery* [25]

Supports healthy metabolism*

Supports healthy blood glucose levels* [26–32]

Supports healthy leptin signaling* [15,31]

Supports healthy feeding behaviors* [15,17]

Supports lean mass* [25]

Supports healthy immune system function*

Supports innate immunity* [33–37]

Supports adaptive immunity* [33,34,37–46]

Supports immune system communication* [37,47–49]

Supports healthy immune signaling* [15,29,50]

Enhances antioxidant defenses*

Supports antioxidant defenses* [11–13,32,51]

Replenishes glutathione (GSH) levels* [11,13,32]

Counters ROS levels and oxidative stress* [11,13,14,21]

Supports healthy thyroid function*

Supports thyroid function* [52–54]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, cure, or prevent any disease.

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