Gamma-Oryzanol
Gamma-oryzanol (γ-oryzanol) is a mixture of lipid molecules called steryl ferulates. Like many secondary metabolites in plants, and similar to tocopherols which also naturally occur in the oils of seeds, γ-oryzanol is considered to be an antioxidant. The best food source is rice bran and germ—γ-oryzanol gets its name from the botanical name for rice, Oryza sativa. γ-oryzanol has been sold in Japan since 1962, and most of the human studies on it have been done in Japan and published in non-English papers. These studies have focused primarily on supporting aspects of menopause, mood, nervous system, and heart health. Animal studies have suggested cognitive, mood, stress, immune and sleep support functions.*
TOP BENEFITS OF GAMMA-ORYZANOL
Supports antioxidant defenses*
Supports brain function*
QUALIA’S GAMMA-ORYZANOL SOURCING
γ-Oryzanol is sourced from rice bran oil which goes through several extraction steps resulting in a finished product that contains not less than 97% γ-Oryzanol.
γ-Oryzanol is Non-GMO and Vegan.
GAMMA-ORYZANOL FORMULATING PRINCIPLES AND RATIONALE
One of our dosing principles is to determine whether there is a dosing range, in which many of the benefits occur and above which there appears to be diminishing returns (i.e., a threshold), and to provide a dose within this threshold range (see Qualia Dosing Principles ). We consider γ-oryzanol to be one of these threshold compounds. Very modest amounts of γ-oryzanol—10 to 50 mg a day—have been needed to produce a functional benefit in some of the human studies, so we will typically use a serving within this range. In parts of the world where rice bran oil is used or rice bran is consumed, it is a naturally occurring part of the diet; however, there would be a negligible amount found in a typical western diet. The modest serving of γ-oryzanol supplied can be thought of as augmenting the intake of an ingredient that’s not found in a meaningful amount in many people’s diets.*
GAMMA-ORYZANOL KEY MECHANISMS
Supports brain function*
Supports learning and memory (in animals)* [1–4]
Supports histaminergic neurotransmission* [5,6]
Supports adrenergic signaling* [7–9]
Supports serotonin signaling* [7–9]
Supports synaptic plasticity* [1]
Supports brain mitochondrial function and energy metabolism* [1,3,10,11]
Supports neuronal antioxidant defenses* [1,8,12–14]
Supports neuroprotective functions* [13,15–17]
Supports healthy behavioral and physiological responses to stress* [3,7,14,18–22]
Supports non-rapid eye movement (NREM) sleep* [5,6]
Supports antioxidant defenses*
Supports antioxidant enzymes* [1,14,17,23–25]
Supports Nrf2 signaling* [24]
Supports phase II antioxidant enzymes (HO-1, NQO1)* [2,21,24]
Counters ROS production and oxidative stress* [14,17]
Supports healthy aging and longevity*
Supports healthy cardiovascular function* [23,26,27]
Supports healthy kidney function* [28–30]
Supports healthy metabolic function* [30–33]
Supports muscle strength* [34]
Supports immune performance* [35]
Supports mitochondrial function and biogenesis* [3,10,17]
Supports autophagy* [15,36]
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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