Haritaki (Terminalia chebula) Fruit Extract

Haritaki is the Sanskrit name for the fruit of Terminalia chebula, a tree native to South and Southeast Asia.  The name comes from the Sanskrit words harit, which means "green", and aki, which means "fruit." The most common English name for the fruit is black or chebulic myrobalan. T. chebula fruit has a long history of use in Ayurvedic tradition, where it has been described as the "King of Medicines" [1]. It has also been used in Tibetan, Thai, and other South and Southeast Asia healing traditions. The fruits of T. chebula have many traditional uses, including the support of gastrointestinal health, healthy immune defenses, and brain health. T. chebula fruits are rich in vitamin C and polyphenols including tannins, phenolic acids, and flavonoids, all of which have antioxidant properties and support general health and the innate protective mechanisms in several organs of the human body, including the brain [2].*

TOP BENEFITS OF TERMINALIA CHEBULA FRUIT EXTRACT

Supports joint health*

Supports healthy brain function and cognition*

QUALIA’S TERMINALIA CHEBULA FRUIT EXTRACT SOURCING

Haritaki (Terminalia chebula) Fruit Extract is standardized for 35% tannins.

Haritaki (Terminalia chebula) Fruit Extract is a non-GMO, gluten-free, and vegan ingredient. 

TERMINALIA CHEBULA FRUIT EXTRACT FORMULATING PRINCIPLES AND RATIONALE

When used as a single ingredient, standardized T. chebula fruit extracts have been used in human studies at serving sizes ranging from several hundred mg up to 1000 mg daily. When combined with other botanical extracts, such as turmeric and Boswellia, a much lower amount has been supplemented [3]. Since we are supplementing T. chebula fruit extract combined with other herbal extracts, we selected an amount to include that is more consistent with how this fruit extract is used when given in combination with other botanical extracts.*

TERMINALIA CHEBULA FRUIT EXTRACT KEY MECHANISMS

Supports healthy joint function*

(with Curcuma longa rhizome and Boswellia serrata gum resin)

Supports joint comfort* [3]

Supports healthy joint mobility* [3]

Supports optimal joint functionality* [3]

Supports the maintenance of healthy cartilage structure* [4] 

Supports healthy brain function and cognition*

Supports healthy cognitive function* [5–9]

Supports healthy cortisol levels* [10]

Supports healthy behavioral stress responses* [11] 

Supports healthy monoamine (serotonin, dopamine, norepinephrine) balance* [10,11]

Supports healthy acetylcholine signaling* [8,12,13]

Supports healthy BDNF levels* [10,14]

Supports healthy neuroprotective functions* [6–9,12,14]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

REFERENCES
[1]K.K. Ratha, G.C. Joshi, Ayu 34 (2013) 331–334.
[2]M. Nigam, A.P. Mishra, A. Adhikari-Devkota, A.I. Dirar, M.M. Hassan, A. Adhikari, T. Belwal, H.P. Devkota, Phytother. Res. 34 (2020) 2518–2533.
[3]V. Karlapudi, A.V.V. Prasad Mungara, K. Sengupta, B.A. Davis, S.P. Raychaudhuri, J. Med. Food 21 (2018) 511–520.
[4]H.L. Kim, H.J. Lee, D.-R. Lee, B.-K. Choi, S.H. Yang, Molecules 25 (2020) 5467.
[5]M. Banazadeh, M. Mehrabani, N. Banazadeh, F. Dabaghzadeh, F. Shahabi, Phytother. Res. 36 (2022) 543–550.
[6]Q. Zeng, Q. Xiong, K. Lin, Z. Liang, M. Zhou, X. Tian, C. Xu, Q. Ru, Brain Res. Bull. 184 (2022) 76–87.
[7]H. Khazani, B. Jalali Kondori, H. Sahraei, G.H. Meftahi, Brain Res. Bull. 213 (2024) 110975.
[8]M.-S. Kim, D.Y. Lee, J. Lee, H.W. Kim, S.H. Sung, J.-S. Han, W.K. Jeon, BMC Complement. Altern. Med. 18 (2018) 136.
[9]R. Kumar, R. Arora, A. Agarwal, Y.K. Gupta, J. Ethnopharmacol. 215 (2018) 124–131.
[10]Y. Chandrasekhar, G. Phani Kumar, K. Navya, E.M. Ramya, K.R. Anilakumar, J. Pharm. Pharmacol. 70 (2018) 1662–1674.
[11]V. Mani, S. Sajid, S.I. Rabbani, A.S. Alqasir, H.A. Alharbi, A. Alshumaym, Afr. J. Tradit. Complement. Altern. Med. 11 (2021) 493–502.
[12]M.E.A. El-Shamarka, W.M. Aboulthana, N.I. Omar, M.M. Mahfouz, Inflammopharmacology 32 (2024) 1439–1460.
[13]Y.-J. Li, C.-C. Liang, L. Jin, J. Chen, Spectrochim. Acta A Mol. Biomol. Spectrosc. 302 (2023) 123115.
[14]J.H. Park, H.S. Joo, K.-Y. Yoo, B.N. Shin, I.H. Kim, C.H. Lee, J.H. Choi, K. Byun, B. Lee, S.S. Lim, M.J. Kim, M.-H. Won, Neurochem. Res. 36 (2011) 2043–2050.