Magnesium (as Magnesium Sulfate)

Magnesium sulfate is a salt of magnesium containing the sulfate ion. Magnesium is one of the most abundant minerals in the body and is vital for the functioning of all living cells. It’s used in more than 300 enzymes. ATP (i.e., cellular energy) occurs complexed with magnesium, so all enzymes utilizing ATP require magnesium. The same is true for enzymes that synthesize DNA and RNA; magnesium is always involved. Magnesium also plays a large role in breaking down sugars (glycolysis). Because magnesium supports the electrical functions of cells (i.e., it’s an electrolyte), muscle and nerve function rely on magnesium.*

TOP BENEFITS OF MAGNESIUM SULFATE

Supports sleep*

Supports healthy cardiovascular function*

Supports mood balance*

Supports musculoskeletal health*

Supports cellular health*

QUALIA’S MAGNESIUM SULFATE SOURCING

Magnesium sulfate is a non-GMO, gluten-free, and vegan ingredient.

MAGNESIUM SULFATE FORMULATING PRINCIPLES AND RATIONALE

The Recommended Dietary Allowance for magnesium in adults varies from 310 to 420 depending upon age and gender. A majority of Americans of all ages fall somewhat short of this amount. Supplying even a low dose of magnesium can help close the gap. We generally supply it in small amounts to augment dietary intake of magnesium and complement other ingredients in a formula.*

MAGNESIUM KEY MECHANISMS

Supports optimal metabolism and energy generation*

Supports the synthesis of ATP by ATP synthase in mitochondria* [1,2]

Part of a complex with ATP (MgATP) that is required for many rate-limiting metabolic enzymes* [3]

Supports the activity of rate-limiting enzymes involved in carbohydrate and lipid metabolism* [3,4]

Supports the activity of rate-limiting enzymes involved in protein and nucleic acid synthesis* [3,4]

Helps maintain healthy insulin sensitivity* [5,6]

Supports cell signaling*

Supports healthy cellular sodium and potassium influx and efflux* [3]

Supports  healthy cellular calcium influx and balanced calcium signaling* [3,4]

Supports the activity of adenylate cyclase - cyclic adenosine monophosphate (cAMP) synthesis* [7]

Supports cell structure*

Helps maintain the stability of proteins, nucleic acids, chromosomes, and biological membranes* [3]

Supports healthy cardiovascular function*

Supports healthy cardiac muscle contraction and heart rhythm* [4,8]

Supports healthy vascular tone* [4,8]

Supports healthy platelet function* [4,9]

Supports healthy brain function*

Supports healthy hearing* [10–16]

Supports healthy neurotransmitter signaling  and optimal neurological function* [4]

Supports the healthy activity of the glutamate N-methyl-D-aspartate (NMDA) receptor* [17,18]

Supports healthy glutamate dehydrogenase (GDH) enzyme function that converts glutamate to α-ketoglutarate, and vice versa* [19,20]

Supports healthy serotonin N-acetyltransferase function - an enzyme that is involved in the day/night rhythmic production of melatonin from serotonin* [21,22]

Supports healthy brain-derived neurotrophic factor (BDNF) function* [18,23,24]

Supports healthy neural stem cell proliferation* [25]

Supports healthy brain mitochondrial function* [25]

Supports a healthy mood*

Supports mental well-being* [26,27] 

Supports healthy behavioral and physiological responses to stress* [24,28–31] 

Supports sleep* 

Supports optimal sleep quality* [32–35]

Supports healthy EEG and neuroendocrine responses during sleep* [36,37]

Supports sleep organization and regulation* [38–41]

Supports exercise tolerance in contexts of poor sleep* [42]

Supports muscle function*

Supports healthy muscle contraction* [4,43]

Supports optimal muscle strength* [44,45]

Supports the skeletal system*

Supports healthy bone metabolism/remodeling and optimal calcium absorption* [3]

Supports healthy calcitonin and parathyroid hormone activity* [3]

Supports optimal bone formation* [3]

Supports healthy gut microbiota*

Supports a healthy composition of the gut microbiome* [46–48]

Complementary ingredients*

Commonly supplemented with calcium for bone support* 

Supports vitamin D metabolism* [49]

B-complex vitamins and melatonin supplementation for sleep support* [50]

Zinc and melatonin supplementation for sleep support* [51]

Vitamin B6 for mood support* [52,53]

Hawthorn and California poppy for mood support* [54]

Antioxidant vitamins for hearing support* [55–57]

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure, or prevent any disease.

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