Vitamin B6 (as Pyridoxine HCL)
Pyridoxine is a form of vitamin B6, which is part of the B complex—a group of water-soluble vitamins that play important roles in cellular metabolism and energy production. The term vitamin B6 can refer to any of six forms—pyridoxal, pyridoxamine, pyridoxine, and their phosphorylated forms. Pyridoxine is the most common form of vitamin B6 used in dietary supplements. Pyridoxine is metabolized in the body to the active form pyridoxal-5-phosphate (P5P). P5P is a cofactor involved in over 4% of all enzymatic activities, including many metabolic pathways important for cellular energy generation.[1] Major functions of P5P include (1) metabolism of fats, sugars, and proteins, (2) neurotransmitter synthesis, (3) synthesis of the hemoglobin used in red blood cells, and (4) increasing and decreasing the expression of certain genes.*
TOP BENEFITS OF PYRIDOXINE
Supports energy metabolism*
Supports healthy brain function*
Supports general immune health*
QUALIA’S PYRIDOXINE SOURCING
Pyridoxine HCl is a non-GMO, gluten-free, and vegan ingredient.
PYRIDOXINE FORMULATING PRINCIPLES AND RATIONALE
Vitamin B6, no matter the form, is subject to a dosing threshold (see Qualia Dosing Principles), which means, while more might be better within a low to moderate range, very high amounts would be unlikely to add significant additional nutritional or functional benefits for most people but could increase the risk of unwanted responses. Our goal in formulating products is to make sure that vitamin B6 amounts will be comfortably below the levels where the risk for unwanted responses exists, even if several of our products with vitamin B6 are used together. In general, we tend to dose vitamin B6 at higher amounts in formulations where it would be used to support neurotransmitter production, and lower levels when we are using it to complement a full B complex stack. The main role of vitamin B6 in the body is as a coenzyme for metabolic reactions. It is important to have sufficient amounts of vitamin B6 in the diet to allow proper functioning of these enzymes.*
PYRIDOXINE KEY MECHANISMS
Supports energy metabolism*
Cofactor in about 100 essential enzyme reactions, including enzymes of glucose, fatty acid, and amino acid metabolism [2]
Cofactor in the kynurenine pathway; required for the synthesis of NAD+ from tryptophan [3]
Supports hemoglobin synthesis*
Cofactor in the synthesis of heme, an iron-containing molecule found in hemoglobin [4]
Supports healthy brain function*
Cofactor for the enzyme aromatic L-amino acid decarboxylase, which catalyzes the synthesis of serotonin from 5-hydroxytryptophan (5-HTP) and dopamine from L-3,4-dihydroxyphenylalanine (L-DOPA) [5–9]
Since dopamine is a precursor for noradrenaline, P5P is required for its synthesis [8]
Since serotonin is a precursor for melatonin, P5P is required for its synthesis [9]
Supports glutamate decarboxylase (GAD) enzyme - GAD catalyzes the synthesis of gamma-aminobutyric acid (GABA) from glutamate [10–15]
Supports gamma aminobutyric acid transaminase (GABA-T) enzyme - GABA-T catalyzes the breakdown of gamma-aminobutyric acid (GABA) [10,12]
Participates in the metabolism of the neurotransmitters glycine, D-serine, and histamine [16]
Supports the synthesis of neurotransmitters involved in memory, executive function, mood regulation, focus, motivation, and sleep regulation [17]
May support aspects of dream recall (studies have been at doses ≥100 mg) [18,19]
Supports healthy immune function*
Supports adaptive immunity [20–26]
Supports immune system communication [27]
Complementary ingredients*
Vitamin B12 and folic acid (vitamin B9) for cardiovascular support and homocysteine metabolism [28–30], brain support [31], mood [32], and for general well-being [33]
L-tryptophan and melatonin for sleep support [34–38]
Magnesium, other B-complex vitamins, and melatonin supplementation for sleep support [39]
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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