Hi Alejandro, Typically, the biggest issue that will prevent you feeling the full effects of Qualia is sleep. Qualia works along the same pathways in the brain that move your memories from short to long term storage when you sleep. If you are not getting enough sleep or the right kinds of sleep than those pathways are unavailable and you will not feel Qualia working. Additional things that can make it less effective: Not enough healthy fats in your diet Caffeine desensitization Too small a dose Not drinking enough water Cannabis or alcohol use Desensitization from other past stimulants or psychotropic drugs or meds Please reach out to the customer support team at [email protected].